Effects of Δ8- and Δ9-Tetrahydrocannabinol on experimentally induced seizures

Effects of Δ⁸- and Δ⁹-tetrahydrocannabinol (Δ⁸- and Δ⁹-THC) on three experimentally induced seizure models, i.e., audiogenic seizure (AS) test, maximal electroshock seizure (MES) test and pentylenetetrazol (PTZ)-induced seizure test were determined in the audiogenic rat. Both tetrahydrocannabinols possess a dose-related anticonvulsant effect against AS, MES and PTZ-induced maximal seizure. Although anticonvulsant potencies do not significantly differ, Δ⁸THC is three times more neurotoxic than Δ⁹THC. In addition, both THC's are without effect on minimal seizure and lethality induced by PTZ. Furthermore, the low protective indexes (TD50/ED50) determined in this study suggest that Δ⁸ and Δ⁹ THC may have poor therapeutic potentials as antiepileptic drugs.     

Scytinostroma galactinum as a pathogen of woody plants

Scytinostroma galactinum (Fr.)Donk is the fungus commonly known asCorticium galctinum (Fr.)Burt. Although it occurs as a saprobe on woody plants and plant debris, it also has been considered by several authors as an active pathogen that causes a white root and butt or collar rot. During the summer of 1970, it was found near Baltimore and also in Montgomery County, Maryland, under circumstances that seemingly provide additional records of pathogenicity. Several other Maryland records are cited, and many Canadian studies have been reviewed.S. galactinum has a distinctive dextrinoid mycelium, which is characteristic enough to permit a tentative identification even in the absence of other features. Outstanding elements of the basidiocarp are the dextrinoid hyphae and slender gloeocystidia. In culture, dextrinoid fiber hyphae and papillate oil-bearing hyphae with clamp connections are characteristic. These and other features of the basidiocarp and culture serve in the characterization of this fungus, which is economically significant and widely distributed.     

Alterations in high-affinity binding characteristics and levels of opioids in invertebrate ganglia during aging: Evidence for an opioid compensatory mechanism

In Mytilus and Leucophaea the high-affinity binding site density is significantly lower in old animals than in young animals, whereas the low-affinity site density remains unchanged. In Mytilus the estimated met-enkephalin and met-enkephalin-Arg6-Phe7 levels are significantly higher in old than in young animals. In Leucophaea only the met-enkephalin level can be determined, and it is also higher in old animals. The decrease in the high-affinity binding site density and the corresponding increase in endogenous enkephalin levels suggest the existence of an opioid compensatory mechanism associated with the aging process. In Mytilus there is a demonstrated decrease with age in intraganglionic dopamine levels in response to applied opiates. In addition, the inhibition of dopamine-stimulated adenylate cyclase activity by opiates also decreases in older animals. In Leucophaea the sex difference in opioid binding densities diminishes with age.     

On the Detection of Unusual Points in Regression

Some procedures, based on studentized residuals and the diagonal elements of the ‘hat’ matrix, for the detection of unusual points in regression are discussed. These procedures are quite simple but effective to uncover unusual structure of the data. Some examples are given.